Plaquenil retinal toxicity oct

Discussion in 'Northwest Pharmacy Canada' started by Asij, 09-Mar-2020.

  1. liliyamois User

    Plaquenil retinal toxicity oct


    In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio.

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    Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Apr 20, 2011 Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3. The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. Plaquenil Toxicity Screening On rare occasion, and usually after many years, Plaquenil can damage the central portion of the retina, the macula and affect the central, fine visual acuity used for reading.

    As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits.

    Plaquenil retinal toxicity oct

    How to Succeed in Plaquenil Screenings, New Plaquenil Guidelines -

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  4. Sep 15, 2014 Stepien KE, Han DP. Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic visual loss. Trans Am Ophthalmol Soc. 2009; 1–34. PMC free article

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    OCT scan top of normal macula compared to Plaquenil Toxicity bottom with loss of the outer retinal tissue around the macular center red boxes View more retina images at Retina Rocks, the world’s largest online multimedia retina image library and bibliography repository. Aug 06, 2014 Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is relatively rare, estimated at 1 percent after five years and rising with continued therapy. 3 However. Aug 29, 2014 Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy.

     
  5. Kevin Guest

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  6. nonick Well-Known Member

    RA and Your Eyes Complications Rheumatoid Arthritis. The iris is the colored part of the eye that helps control how much light enters. Uveitis is an inflammation of the uvea; iritis, a form of uveitis, is an inflammation of the iris. Symptoms include blurred vision; dark, floating spots in your vision; eye pain; redness; and sensitivity to light.

    Plaquenil Side Effects on Your Eyes and Vision