Low-dose hydroxychloroquine in treatment of porphyria

Discussion in 'Northwest Pharmacy Canada' started by Tert, 23-Feb-2020.

  1. yellA Well-Known Member

    Low-dose hydroxychloroquine in treatment of porphyria


    These disorders are usually inherited, meaning they are caused by abnormalities in genes passed from parents to children. When a person has a porphyria, cells fail to change body chemicals called porphyrins and porphyrin precursors into heme, the substance that gives blood its red color.

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    Oct 30, 2019 Porphyria cutanea tarda. Data from a randomized, nonblinded pilot study support the use of hydroxychloroquine in the treatment of porphyria cutanea tarda Singal 2012. Primary Sjögren syndrome extraglandular manifestations Therapeutic phlebotomy is the removal of about a pint of blood from a vein in the arm. A technician performs the procedure at a blood donation center, such as a hospital, clinic, or bloodmobile. A patient does not require anesthesia. Another treatment approach is low-dose hydroxychloroquine tablets to reduce porphyrins in the liver. Background & Aims. Porphyria cutanea tarda PCT is an iron-related disorder caused by reduced activity of hepatic uroporphyrinogen decarboxylase; it can be treated by phlebotomy or low doses of hydroxychloroquine.

    Bone marrow is the soft, spongelike tissue inside the bones; it makes stem cells that develop into one of the three types of blood cells—red blood cells, white blood cells, and platelets. The body makes heme mainly in the bone marrow and liver.

    Low-dose hydroxychloroquine in treatment of porphyria

    Low-Dose Hydroxychloroquine is as Effective as Phlebotomy in Treatment., Porphyria NIDDK

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  4. Porphyria cutanea tarda PCT is a term encompassing a group of acquired and familial disorders in which activity of the heme synthetic enzyme uroporphyrinogen decarboxylase UROD is deficient. Approximately 80% of all cases of porphyria cutanea tarda are acquired; 20% are familial, although the ratio may vary among different geographic regi.

    • Porphyria Cutanea Tarda Treatment & Management Medical..
    • Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in Treatment..
    • Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy..

    The recommended dosages are 100 mg twice a week for hydroxychloroquine or 125 mg twice a week for chloroquine. Such a low dose schedule is equally effective as phlebotomy and easier to take with less treatment cost involved. Has been used in treatment of porphyria cutanea tarda†. 114 116 117 See Patients with Psoriasis or Porphyria under Cautions. Has been effective in some cases when used in the treatment of polymorphous light eruptions†. Hydroxychloroquine Sulfate Dosage and Administration Administration Oral Administration. Administer orally. 109 Treatment of porphyria cutanea tarda can include Regular blood removal phlebotomies to reduce the amount of iron in the liver Low doses of the antimalarial drug chloroquine or hydroxychloroquine

     
  5. PythonOleg Guest

    Suppression: 400 mg (310 mg base) orally on the same day every week Comments: -Suppressive therapy should begin 2 weeks prior to exposure; however, failing this, an initial dose of 800 mg (620 mg base) may be taken in 2 divided doses (6 hours apart). KDIGO GN Guideline update – Evidence summary Lupus nephritis Hydroxychloroquine Remains a Workhorse in Lupus Nephritis. Lupus Nephritis Medication Corticosteroids.
     
  6. Miroslav User

    This is not a list of all drugs or health problems that interact with hydroxychloroquine. Plaquenil Side Effects on Your Eyes and Vision Plaquenil Side Effects Common, Severe, Long Term - Plaquenil Uses, Dosage & Side Effects -
     
  7. Wom New Member

    CDC - Malaria - Diagnosis & Treatment United States. Persons acquiring P. vivax infections in Papua New Guinea or Indonesia should initially be treated with a regimen recommended for chloroquine-resistant P. vivax infections. The treatment regimens for chloroquine-resistant P. vivax infections are quinine sulfate plus doxycycline or tetracycline, or, atovaquone-proguanil, or artemether.

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