Chloroquine mechanism of action in sle

Discussion in 'Northwest Pharmacy Canada' started by WwW-WwW-WwW, 18-Mar-2020.

  1. Gyrus Moderator

    Chloroquine mechanism of action in sle


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

    Chloroquine hcc Conditions that plaquenil treats Chloroquine adme

    Medical use. Hydroxychloroquine treats malaria, systemic lupus erythematosus, rheumatic disorders like rheumatoid arthritis, porphyria cutanea tarda, and Q fever. In 2014, its efficacy to treat Sjögren syndrome was questioned in a double-blind study involving 120 patients over a 48-week period. Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Mechanism of action The precise mechanism by which hydroxychloroquine exhibits activity against Plasmodium is not known. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine mechanism of action in sle

    Mechanisms of action of hydroxychloroquine and chloroquine., Plaquenil - FDA prescribing information, side effects and uses

  2. Allergic to plaquenil
  3. Antimalarial mode of action and resistance. Chloroquine acts exclusively in the erythrocyte stage of malaria parasites. The antimalarial mechanism of action from chloroquine has not been fully elucidated.

    • Chloroquine Modes of action of an undervalued drug..
    • Hydroxychloroquine DermNet NZ.
    • Hydroxychloroquine and Chloroquine Phosphate - RheumaKnowledgy.

    Chloroquine is still the drug of choice for the treatment of susceptible strains of P. falciparum and the other 3 malarial species; however, chloroquine-resistant P. vivax has recently been reported {36} {56}. Various autoimmune disease such as colitis, RA, and SLE are known to be caused by different cell types and mechanisms 42. Nevertheless, from a T cell perspective, they are commonly induced by T H. Its mechanism of action is unknown; however, malarial parasites invade human red blood cells, and chloroquine may prevent malarial parasites from breaking down metabolizing hemoglobin in human red blood cells.

     
  4. radsansei New Member

    I am interested to see if anyone here has gotten a rash from Plaquenil after being on it for several months. Photosensitivity Reaction With Certain Medications Plaquenil Side Effects Common, Severe, Long Term - Rashes, Skin Care and Cutaneous Lupus What You Should Know
     
  5. antonyzoom New Member

    Selective Thinning of the Perifoveal Inner Retina as an Early. Selective Thinning of the Perifoveal Inner Retina as an Early Sign of Hydroxychloroquine Retinal Toxicity Sirichai Pasadhika, 1 Gerald A Fishman, 1 Dongseok Choi, 2 and Mahnaz Shahidi 1 1 Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL

    Choroidal Thinning Associated With Hydroxychloroquine Retinopathy.
     
  6. Goodmen5 Moderator

    Hydroxychloroquine, Serum - Northwell Health Laboratories Hydroxychloroquine is an antimalarial drug used to treat or prevent malaria. It is highly effective against erythrocytic forms of Plasmodium, but not effective against exoerythrocytic forms of parasites. Hydroxychloroquine is also used to treat symptoms of acute or chronic rheumatoid arthritis and lupus erythematosus.

    Hydroxychloroquine Plaquenil RheumTutor