I have been on plaquenil for over a year and a half and methotrexate since September. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes (used to be every 2 weeks). I have lupus which mainly affects my joints and skin. One affects your eyes more and one affects your liver more. I would appreciate any comments or advice from everyone. Wannabe Hi, I am on both methotrexate and plaquenil. Wannabe To Be Free To Roam Sorry to hear that you are having a lot of pain with your RA. Lyme and plaquenil Sulfasalazine and hydroxychloroquine rheumatoid arthritis Plaquenil generic brand Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in antigen presentation or effects on the innate immune system. Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and. Prescribed for Lyme Disease - Arthritis, Dermatomyositis, Malaria Prevention, Malaria, Rheumatoid Arthritis. Reportedly 64 percent of infections that occur in patients with RA occur in the foot and ankle. In order to minimize the risks of infection and other potential complications with podiatric surgery in this patient population, this author reviews the literature and offers insights on whether medications for RA should be withdrawn, continued or modified during the perioperative period. I wish you well with this decision and the results. Your chances of problems with the methotrexate are a bit larger. deductible (I am at about $2,500 - $3,000 right now). My rheumy recently added Imuran (instead of methotrexate). So, what do yall know about the side effects of both and the benefits of both? Do i need hydroxychloroquine with methotrexate Methotrexate Side-effects, uses, time to work, Methotrexate vs Plaquenil Comparison - Home remedies plaquenil hyperpigmentationPlaquenil dosageChloroquine based chalcone One option mentioned in the ACR guidelines is to try multiple DMARD therapy without biologics. This is sometimes called “triple therapy” and includes methotrexate, hydroxychloroquine Plaquenil, and sulfasalazine. Switching Medications Without Waiting too Long RA. A Guide To Perioperative Management Of The Rheumatoid Patient.. Common Questions About Taking Methotrexate for Rheumatoid.. Try to avoid people with infections like colds or flu. Wash your hands regularly. Tell your doctor if you have fever, chills, or a cough. Don’t take live vaccines like the nasal flu mist, measles, mumps, or shingles shots while you take methotrexate. Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. Dec 15, 2010 just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly. now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. i'm not expecting it to work over night but soon hopefully.