Try refreshing the page, or returning to the homepage. If the problem continues, please visit our support portal. Hydroxychloroquine dosage rheumatoid arthritis Chloroquine or mefloquine resistance malaria Chloroquine children Chloroquine sugar cravings Study design. The study is a single-centre, double blinding and 24-week randomized and controlled trial with two arms, in one of which, needles will be inserted into previously set acupoints while sham acupuncture for the other group. 120 patients with symptomatic pSS are randomly assigned to acupuncture or sham acupuncture groups in 11 ratio. Randomized controlled trials are needed to provide evi-dence either for or against the use of TENS in xerostemia. Citation Sivaramakrishnan G, Sridharan K. Electrical nerve stimulation for xerostemia a meta-analysis of randomized controlled trials. Journal of Traditional and Complementary Medicine. 2017 October. 74;409-413. Methods/Design. OA TREAT is an investigator-initiated, multicenter, randomized, double-blind, placebo-controlled trial. A total of 510 subjects with inflammatory and erosive hand OA, according to the classification criteria of the American College of Rheumatology ACR, with recent X-ray will be recruited across outpatient sites, hospitals and universities in Germany. HCQ blocks IFN activation, which is present in half of the p SS patients. HCQ is frequently used to treat primary SS (p SS), but evidence for its efficacy is limited. Randomized controlled trial hydroxychloroquine sjogren Inefficacy of Hydroxychoroquine in. - ACR Meeting Abstracts, Top Stories Sjögren’s What is aralen used forNatural antibiotics for lyme plaquenilDoes hydroxychloroquine cause cirrhosis Stratification on the basis of patient-reported symptoms of patients with primary Sjögren's syndrome revealed distinct pathobiological endotypes with distinct responses to immunomodulatory treatments. Our data have important implications for clinical management, trial design, and therapeutic development. Similar stratification approaches might be useful for patients with other chronic immune. Symptom-based stratification of patients with primary Sjögren's.. Hydroxychloroquine in patients with inflammatory and erosive.. Hydroxychloroquine treatment downregulates. From April 2008 to May 2011, 120 patients with primary Sjögren syndrome according to American-European Consensus Group Criteria from 15 university hospitals in France were randomized in a double-blind, parallel-group, placebo-controlled trial. Participants were assessed at baseline, week 12, week 24 primary outcome, and week 48. To investigate further the clinical and laboratory effects of hydroxychloroquine in primary Sjögren's syndrome a two year study was performed. METHODS The design of the study included a prospective, placebo controlled, two year double blind crossover trial in 19 patients. Historically, patients with primary Sjögren syndrome have had few effective, biologic options, but ongoing clinical trials may offer promising new options. Worldwide, several drugs are being tested in small, randomized trials in the hopes that they may produce targeted treatment for specific manifestations of the disease.