Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil night vision Does chloroquine sulfate have sulfa in it Plaquenil “ Side Effects Severe abdominal pain, bloating, constipation. Increased leg spasms @ night. Hair loss, accelerated depression. At the 4th week, itchy, red dots appear along with scalp itching. ” Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Im newly diagnosed and been on Plaquenil for a week but it is making me really constipated. Ive resorted to having some Lactulose with good effect. Does anyone else have this side effect? Is it ok to use the Lactulose? Can it be used long term if required? Does anyone have any tips or natural remedies for constipation? Madwife Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil side effects constipation Let me tell you what weaning down from Plaquenil is like., Hydroxychloroquine Side Effects Common, Severe, Long Term. Quinine vs chloroquine What are the possible side effects of antimalarial drugs? Plaquenil is most often well-tolerated but, like with any drug, side effects are possible. Most people about 90% who take antimalarial medications experience no side effects. If common side effects do occur, they are usually minor and last only for a short period of time. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Plaquenil and constipation Lupus Forums at The Lupus Site. Plaquenil & Weight Gain/Loss -. Hi I think that Lucy may be correct in that the constipation may be caused from your Lupus. Normally, Plaquenil causes the opposite effect with diarrhea being the problem. I've not heard of anyone mentioning constipation as the side effect. That's not to say it doesn't happen though. I would contact your Rheumy and see what they have to say. Hydroxychloroquine Side Effects Get emergency medical help if you have signs of an allergic reaction hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Re Prednisone, plaquenil and constipation. I haven't experienced any problems with constipation while on prednisone and plaquenil. I had a lot of bowel trouble before I was DXD though, which may be why I am not having problems now, could be that the drugs just evened me out so to speak.