However, it can interact with some common medications, altering their effects on your body. If you're curious about the grapefruit warning on many medicines, this article will help you understand why it's there and what your options are. Chloroquine glycosylation Deae dextran chloroquine method If you are taking antidepressants A common medication for depression is a selective serotonin receptor uptake inhibitor or SSRI. This particular antidepressant medication increases fracture risk and bone loss in older women and is associated with lower bone density in children and men. To lessen the harm to the bones from antidepressants The only side effects from Plaquenil that most of us notice is possibly an upset stomach for a few days.sure to take with food. Depression, anxiety, and brain fog could be Lupus symptoms -- or they could be from Remicade, I'm not familiar with it's side effects. Balances out the steroids and im guessing, the Plaquenil, because I had weird issues before with Plaquenil and this time I don't. I know they can be addictive so im careful, and I respect them, I try to skip if I can, but between anxiety from pills helping me to live better, and addicted to nerve pills, I choose all the above and lead a calm life Medications are processed in your liver and small intestine by a specialized group of proteins called cytochrome P450 (CYPs). Here's a closer look at 32 common drugs that may have dangerous interactions with grapefruit, as well as some alternatives. Plaquenil and antidepressants Hydroxychloroquine Oral Route Description and Brand Names., Plaquenil - Lupus Wolpin oncologist 2014 hydroxychloroquine Bone mineral density problem #5 Antidepressants If you suffer from moderate to severe depression, selective serotonin reuptake inhibitors SSRIs can lift the fog and make you feel more content. Types of Drugs That Affect Bone Mineral Density. Anxiety and Plaquenil Has anyone experienced mood. - LUPUS UK. Anxiety, depression and suicidal ideation in patients with.. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Doxepin Major Avoid coadministration of hydroxychloroquine and tricyclic antidepressants. Hydroxychloroquine increases the QT interval and should not be administered with other drugs known to prolong the QT interval. Ventricular arrhythmias and torsade de pointes have been reported with the use of hydroxychloroquine. I feel like my meds are battling each other. The plaquenil gives me very vivid dreams. I wake up and my pillow is on the floor along with my covers. I can't catch a break with this and need to feel better. For starters I think I am going to lower my plaquenil dose to 200/day instead of 400.