Return of chloroquine antimalarial efficacy in malawi

Discussion in 'Chloroquine Drug' started by princese, 17-Mar-2020.

  1. hostingsale Well-Known Member

    Return of chloroquine antimalarial efficacy in malawi


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    Return of Chloroquine-Susceptible Falciparum Malaria in Malawi Was a Reexpansion of Diverse Susceptible Parasites Miriam K. Laufer 1, Shannon Takala-Harrison 1, Fraction K. Dzinjalamala 5, O. Background. The return of chloroquine-sensitive Plasmodium falciparum to the limited area of Blantyre, Malawi, has been well demonstrated in several studies. Methods. To characterize chloroquine susceptibility over a wide geographic area, infants and children aged 6–59 months were selected using 2-stage cluster sampling in 8 Malawian districts. The spread of drug-resistant Plasmodium falciparum malaria has been a major impediment to malaria control and threatens prospects for elimination. We recently demonstrated the return of chloroquine-susceptible malaria in Malawi after chloroquine use was abandoned.

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    Return of chloroquine antimalarial efficacy in malawi

    The return of chloroquine-susceptible Plasmodium., Return of Widespread Chloroquine-Sensitive Plasmodium.

  2. Hydroxychloroquine for sjogren's syndrome vs another drug
  3. Background. The spread of resistance to chloroquine CQ led to its withdrawal from use in most countries in sub-Saharan Africa in the 1990s. In Malawi, this withdrawal was followed by a rapid reduction in the frequency of resistance to the point where the drug is now considered to be effective once again, just nine years after its withdrawal.

    • Chloroquine resistance before and after its withdrawal in..
    • Return of Chloroquine-Susceptible Falciparum Malaria in..
    • Sustained clinical efficacy of sulfadoxine-pyrimethamine for..

    Insufficient data exist on the antimalarial prophylactic efficacy of related compounds such as minocycline commonly prescribed for the treatment of acne. People on a long-term regimen of minocycline who need malaria prophylaxis should stop taking minocycline 1–2 days before travel and start doxycycline instead. All travelers should seek medical attention in the event of fever during or after return from travel to areas with malaria. 5. This risk estimate is based largely on cases occurring in US military personnel who travel for extended periods of time with unique itineraries that likely do not reflect the risk for the average US traveler. However, the spread of resistance may be reversible. Malawi was the first country to discontinue chloroquine use due to widespread resistance. Within a decade of the removal of drug pressure, the molecular marker of chloroquine-resistant malaria had disappeared and the drug was shown to have excellent clinical efficacy.

     
  4. hostnadzor Moderator

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Use of hydroxychloroquine to prevent thrombosis in systemic lupus. Managing and Treating Lupus and Antiphospholipid Syndrome. Antiphospholipid Syndrome -
     
  5. voidus Moderator

    500 mg chloroquine phosphate (300 mg base) orally on the same day each week Comments: -If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate (600 mg base) may be taken orally in 2 divided doses, 6 hours apart. Efficacy of chloroquine plus primaquine treatment and pfcrt mutation in. Safety and Efficacy of Different Regimens of Primaquine on Vivax. Primaquine Therapy for Malaria Clinical Infectious Diseases.
     
  6. abilio User

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  7. 777 New Member

    Atovaquone-Proguanil versus Chloroquine-Proguanil for Malaria. Jun 15, 2004 Resistance to chloroquine among parasites is widespread, and mefloquine has been associated with potentially serious neuropsychiatric side effects 17, 18. Although it has been approved for treatment in children who weigh 5 kg and chemoprophylaxis for children who weigh 11 kg, atovaquone-proguanil has not been widely tested for prophylaxis in nonimmune pediatric travelers.

    Malaria an update on treatment of adults in non-endemic countries