Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine contraindicated in pregnancy Chloroquine cancer clinical trial Helpful, trusted answers from doctors on Does plaquenil hydroxychloroquine for sle lupus make you gain weight? Re want to know good stuff about plaquenil Hi Aspen.answer to your question, I have been diagnosed PlaquenilName brand-Not the generic form twice in my life, about 15 yrs ago for Sjogren's Syndrome-for about a year & then again last year when I was diagnosed with Lupus. Yes, Plaquenil causes both weight loss and loss of appetite. Hence, if the loss of appetite and weight loss started after you started on this drug, then yes, it could be due to Plaquenil. However, if you had loss of appetite and weight loss before your started this drug, then the drug can aggravate the process. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil weight gain lupus Lupus Medications and Treatments, Want to know good stuff about plaquenil - HealthBoards Hydroxychloroquine sulfate rash Nov 12, 2019 Selena Gomez opened up about her lupus, kidney issues, and medication causing weight gain on a podcast. She says she's “very happy with living my life” now. Selena Gomez Reveals Weight Gain Is Due To Lupus Medication. Plaquenil and loss of appetite - Lupus - MedHelp. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Ideal body weight Plaquenil dosing calculations are reprinted with permission from The Lupus Encyclopedia A Comprehensive Guide for Patients and Families, by Donald E. Thomas, published by Johns Hopkins University Press. The symptoms of lupus vary wildly—from unexplained weight loss to rashes. As a result, it's rare for patients to show up at the doctor's office with symptoms that clearly point to the disease. Weight gain while on Plaquenil? I'm curious if anyone else has experienced weight gain after beginning treatment with plaquenil. I know that the medication is known to cause weight loss and decreased appetite, but I've found that since starting treatment I've gained weight and nothing seems to budge it.