Fluorescein angiography and hydroxychloroquine maculopathy screening

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  1. wings Well-Known Member

    Fluorescein angiography and hydroxychloroquine maculopathy screening


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Fluorescein angiography showed the atrophic window defect characteristic of hydroxychloroquine maculopathy. On June 10, 1999 her Humphrey 10-2 visual field showed an annular scotoma bilaterally. Follow up on December 7, 1999 showed stable 20/50 best-corrected visual acuity and unchanged Humphrey 10-2 visual fields Figure 6, Figure 7. Fluorescein Angiography. Fluorescein angiography can recognize subtle RPE defects, but it has not proven to be more sensitive than tests of functional loss or noninvasive retinal imaging. Full-field Electroretinogram. The full-field ERG is a global test of retinal function and will only show abnormalities in very late CQ or HCQ toxicity. Nov 14, 1998 Editor —The articles cited by May et al confirm that the incidence of hydroxychloroquine retinopathy resulting in permanent or progressive visual loss is extremely low. If the drug was introduced today it would be difficult to justify the initiation of a screening programme.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Fluorescein angiography and hydroxychloroquine maculopathy screening

    Retina Today - Imaging in Hydroxychloroquine Toxicity April., Revised Recommendations on Screening for Chloroquine and.

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  3. Fluorescein angiography FA Optical coherence tomography OCT Fundus autofluorescence; Multifocal electroretinograms mf ERG. Early detection of any maculopathy is critical to prevent central visual loss. The Retina Group of New York provides all of these testing modalities and is the only center on Long Island with mf ERG. Treatment

    • Plaquenil Toxicity Screening - Retina Group of New York.
    • Screening for hydroxychloroquine retinopathy Screening..
    • Screening for hydroxychloroquine retinal toxicity Current..

    New Guidelines for Hydroxychloroquine Visual Screening. Christina M. Sorenson, OD. the risk of converting to hydroxychloroquine retinopathy is 4% every year thereafter. fluorescein. Mar 01, 2011 Fluorescein angiography demonstrated bilateral bull's eye–type pigmentary abnormalities Figures 7-8. This case demonstrates that advanced visual loss can occur with little or no changes detectable on dilated fundus examination, and that ancillary testing is important in screening for early disease. Figures 1 and 2. A pilot study conducted in 15 patients on chloroquine or hydroxychloroquine therapy found that the 10 patients with known or suspected toxicity—based on standardized visual field testing, fluorescein angiography, or both—all demonstrated significant hyperacuity defects on PHP testing.

     
  4. Roman_777 Guest

    A common treatment regimen for the various forms of spondyloarthritis (ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis, reactive arthritis, juvenile spondyloarthritis, and undifferentiated spondyloarthritis) involves medication, exercise, physical therapy, good posture practices, and other options such as applying heat/cold to help relax muscles and reduce joint pain. Lupus and Spondyloarthropathy - Treato Ankylosing Spondylitis RheumTutor Experience with Plaquenil?
     
  5. PerfectO_ua Well-Known Member

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Plaquenil and corona lupus Plaquenil Hydroxycholorquine - Arthritis - MedHelp Vasculitis in Sjogren’s Syndrome
     
  6. Philipp User

    Chloroquine - FDA prescribing information, side effects and uses Oct 01, 2018 The dosage of Chloroquine phosphate is often expressed in terms of equivalent Chloroquine base. Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg Chloroquine base. In infants and children the dosage is preferably calculated by body weight.

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