One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. What are the most common side effects of plaquenil Plaquenil vision changes Hydroxychloroquine warnings Optometric testing for plaquenil toxicity Plaquenil toxicity isn’t even in the top 10, or the top 100” if you’re looking at incidence, he said. “It’s a pretty rare thing.” Nevertheless, he urged doctors to master the Academy’s new guidelines, because the effects from chloroquine and hydroxychloroquine, when they do occur, are severe and often irreversible. Effects of a Plaquenil overdose may include, but are not limited to Headaches. Drowsiness. Vision changes. Seizures. Cardiac arrest. An irregular heart rhythm arrhythmia. Loss of life. Jivrajka RV, Genead MA, McAnany JJ, Chow CC, Mieler WF. Microperimetric sensitivity in patients on hydroxychloroquine Plaquenil therapy. Eye Lond 2013;27 91044-1052. Martinez-Costa L, Victoria Ibanez M, Murcia-Bello C, et al. Use of microperimetry to evaluate hydroxychloroquine and chloroquine retinal toxicity. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Signs of plaquenil overdose Despite Plaquenil dosing recommendations, retinal toxicity., Plaquenil Overdose - Antibiotics Home Page Plaquenil causes dry eyesHow many people taking hydroxychloroquineCan finger joints heal lupus long term usage hydroxychloroquineChloroquine dosing prophylaxisPlaquenil tablets hydroxychloroquine sulphate Aug 29, 2014 The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. The Risk of Retinal Toxicity with Plaquenil. Multimodal Imaging in Plaquenil Toxicity. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. If experienced, these tend to have a Severe expression. A Disorder Of The Retina Of The Eye; Clinical monitoring for signs and symptoms of cardiomyopathy is advised, including use of appropriate diagnostic tools such as ECG to monitor patients for cardiomyopathy during Plaquenil therapy. Chronic toxicity should be considered when conduction disorders bundle branch block/atrio-ventricular heart block or biventricular hypertrophy are. Symptoms of Plaquenil toxicity are similar to other macular problems and may include Decreased fine vision or difficulty reading. Changes in Color vision. Missing Spots or shadows near the center of the vision.