Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil how does it work Malaria prophylaxis with chloroquine Jan 15, 2020 Skin hyperpigmentation is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Omniscan, and have Arteriogram JAMA Dermatol. 2013 Aug;1498935-40. doi 10.1001/jamadermatol.2013.709. Hydroxychloroquine-induced pigmentation in patients with systemic lupus erythematosus a. I also have pigmentation on areas of my body - maily my arms/elbows. It also gets better or worse depending on how high of a dose I am of Plaq. The lower the dose 200mg the lighter the pigmentation is, the higher the dose 400mg/day the darker and larger the spots get. weird. Rheumy said to not worry about it. It doesn't hurt, itch etc. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil and hyperpigmentation Will you have Skin discoloration - bluish with Plaquenil., Hydroxychloroquine-induced pigmentation in patients with. Chloroquine hyperpigmentation Home August 2013 - Volume 19 - Issue 5 Hydroxychloroquine-Induced Hyperpigmentation. Log in to view full text. If you're not a subscriber, you can You can read the full text of this article if you-- Select an option -- Log In Buy This Article Become a Subscriber Hydroxychloroquine-Induced Hyperpigmentation JCR.. Skin Pigmentation & darkening.. Skin Pigmentation with Hydroxychloroquine Plaquenil.. Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. We report two cases of hydroxychloroquine-induced hyperpigmentation presenting in a 50-year-old Caucasian female case 1 and a 78-year-old female case 2, both receiving 400 mg per day. Case 1 had an arthritis predominant undifferentiated connective tissue disease, which was treated with hydroxychloroquine for 4-5 years. Drug-induced pigmentation is not generally associated with any systemic toxicity and thus has an excellent prognosis. With some exceptions, pigmentation is usually reversible and slowly fades with discontinuation of the drug.