Treatment of porphyria cutanea tarda with chloroquine

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    Treatment of porphyria cutanea tarda with chloroquine


    Porphyria Cutanea Tarda (PCT) is a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin (photosensitivity). Affected skin is fragile and may peel or blister after minor trauma. PCT is essentially an acquired disease, but some individuals have a genetic (autosomal dominant) deficiency of UROD that contributes to development of PCT.

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    Seven patients with porphyria cutanea tarda received a total of ten courses of low-dose oral chloroquine therapy 125 mg chloroquine phosphate twice weekly. Patients were treated for a mean 14.9 months during which time all went into clinical and biochemical remission. Porphyria cutanea tarda PCT is common in Ethiopia and invariably affects the liver. Treatment by abstension from alcohol and avoidance of direct sunlight often failed to achieve lasting improvement. Two cases of infantile porphyria cutanea tarda successful treatment with oral S-adenosyl-L-methionine and low-dose oral chloroquine. Br J Dermatol. 1987 Mar. 1163407-15. Bruce AJ, Ahmed I. Childhood-onset porphyria cutanea tarda successful therapy with low-dose hydroxychloroquine Plaquenil.

    Most individuals with the inherited enzyme deficiency remain latent and never have symptoms. These individuals are referred to as having "familial PCT".

    Treatment of porphyria cutanea tarda with chloroquine

    Porphyria Cutanea Tarda Effects and Risk Factors for., Chloroquine in the treatment of porphyria cutanea tarda.

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  3. Introduction. Porphyria cutanea tarda PCT is the most common human porphyria, and is due to an acquired deficiency of hepatic uroporphyrinogen decarboxylase UROD activity, resulting in accumulation of the uroporphyrinogen and other highly carboxylated porphyrinogens in the liver, which then enter the plasma mostly as oxidized porphyrins and are excreted in urine.

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    Porphyria cutanea tarda, the most common type of porphyria worldwide, is caused by a deficiency of uroporphyrinogen decarboxylase, a crucial enzyme in heme biosynthesis, which results in an accumulation of photosensitive byproducts, such as uroporphyrinogen, which leads to the fragility and blistering of sun-exposed skin. Low-dose hydroxychloroquine or chloroquine. These drugs are recommended for patients in whom phlebotomy is contraindicated, difficult, or poorly tolerated. 15 Singal AK, Kormos-Hallberg C, Lee C, et al. Low-dose hydroxychloroquine is as effective as phlebotomy in treatment of patients with porphyria cutanea tarda. Nov 18, 2017 Treatment of acute porphyria attacks focuses on providing rapid treatment of symptoms and preventing complications. Treatment may include Injections of hemin, a medication that is a form of heme, to limit the body's production of porphyrins; Intravenous sugar glucose, or sugar taken by mouth, if able, to maintain an adequate intake of carbohydrates

     
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    Hydroxychloroquine Prices, Coupons & Patient Assistance. Hydroxychloroquine Prices, Coupons and Patient Assistance Programs. Hydroxychloroquine is a member of the antimalarial quinolines drug class and is commonly used for Dermatomyositis, Lyme Disease - Arthritis, Malaria, and others. Brand names for hydroxychloroquine include Plaquenil. Hydroxychloroquine Prices

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