In approximately 51–70% of people with this disease, serum Ig G4 concentrations are elevated during an acute phase. It is a relapsing–remitting disease associated with a tendency to mass forming, tissue-destructive lesions in multiple sites, with a characteristic histopathological appearance in whichever site is involved. Plaquenil retinopathy pathogenesis Order plaquenil Hydroxy chloroquine 200 mg 5 line raster oct plaquenil Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. She was diagnosed with overlapping syndrome of IgG4 related disease and SLE. She was started on 10 mg prednisone and 200 mg plaquenil daily, which significantly improved her symptoms. Her prednisone was tapered slowly and completely discontinued in 5 months. She is currently on maintenance plaquenil 200 mg daily back to her usual state. IgG4‐related disease IgG4‐RD is a recently described fibro‐inflammatory disease affecting nearly every organ system including lymph nodes, periorbital tissues, salivary glands, kidneys, lungs, breast, prostate, thyroid, lungs, meninges, large vessels, and pancreas 1. Ig G4-related disease has been described as an indolent condition. Inflammation and the deposition of connective tissue in affected anatomical sites can lead to organ dysfunction, or even organ failure, if not treated. Plaquenil igg4 disease IgG-4 Related Disease An Introduction, An Overlapping Case of IgG4-Related Disease and Systemic. Hydroxychloroquine sulfate and alcoholDifference between hydroxychloroquine and chloroquine Various hypotheses suggested include an aberrant immunological response to cancer therapies or neo-antigen exposure in malignancy and the development of autoimmune mediated disease and IgG4-RD. Hydroxychloroquine, metabolic reprogramming and reduced incidence of diabetes in connective tissue diseases IgG4-mediated disease and potential risk of malignancy QJM.. Polyclonal hyperviscosity syndrome in IgG4‐related disease.. IgG4-related disease Genetic and Rare Diseases Information.. INTRODUCTION IgG4-related disease IgG4-RD is an emerging systemic inflammatory disease involving nearly all organs eventually leading to fibrosis. Prompt and adequate treatment to prevent irreversible organ damage is therefore pivotal. To evaluate the treatment outcomes, we studied a well-defined cohort of patients with IgG4-RD. Plaquenil may increase the serum concentration of ciclosporin Sandimmun Neoral and digoxin a cardiac medicine Plaquenil may increase the effect of Insulin and other diabetes treatment; Plaquenil can reduce the effect of medication against epilepsy; Psoriasis skin disease can be aggravated by Plaquenil reference Wolf R, 1999 Patient information IgG4-RD may spontaneously disappear, persist or flare from time to time, requiring a temporary increase in treatment. The duration of treatment for patients with IgG4-RD is not clear and each case should be discussed individually with the doctors. Key Points. IgG4-RD is a rare autoimmune disease that may be present for months or even years.