I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Hair loss hydroxychloroquine How to taper off plaquenil 5 line raster oct plaquenil Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. I have been taking the plaquinil for about 8 years morning and night and the prednisone off and on. The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. What time should i take my prednisone and my plaquenil Best time to take plaquenil - HealthBoards, Prednisone and Plaquenil DailyStrength Reticulocytes chloroquine treatment Jessie, plaquenil can take up to 6 months to take effect. I was told to not not try to discontinue any of my lupus meds while my medical condition was unstable. At the time, I had a sinus infection. Jessie, 3 years ago, my doctor discontinued my plaquenil ie. hydroxychloroquen and substituted it for an older anti-malerial drug named "chloroquin". Prednisone and Plaquenil question" Lupus Community.. Taking Plaquenil for Rheumatoid Arthritis. Plaquenil? I have been on prednisone for 15 months.. Plaquenil and Prednisone. By Ang May 4, 2015 at pm. I have been on plaquenil for about 3 months and prednisone for about 5 months. Daily I still get pain and stiffness in my hands and feet. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. I have been on plaquenil for 5 years and immune suppressants for three and this is the first time they have said anything about stopping when taking antibiotics. I would have asked, but the appointment was running super late and my blood pressure was way up by the time the dr came into see me.