Malaria resistance to chloroquine

Discussion in 'Buy Chloroquine Online' started by Gs.Pisuch, 10-Mar-2020.

  1. hardms Well-Known Member

    Malaria resistance to chloroquine


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Chloroquine-resistant malaria is exactly what it sounds like—particular types of malaria which are not cured by treatment with chloroquine. Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. But just when malaria appeared to be well on its way to eradication, this parasitic protozoan mutated in ways that has enabled it to resist frontline antimalarial drugs. This resistance is a major reason that malaria, one of the world’s oldest diseases, still claims the lives of about 400,000 people each year 1. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    Malaria resistance to chloroquine

    Chloroquine - Wikipedia, Chloroquine-resistance transporter – NIH Director's Blog

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  6. Chloroquine, an anti-malaria drug that President Trump fast-tracked for clinical testing this week in the fight against coronavirus, can be deadly for kids, according to an Oklahoma family who said

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    To prevent malaria, take chloroquine once weekly on the same day each week, or as directed by your doctor. Start this medication usually 1 to 2 weeks before you enter the malarious area, continue. Malaria Information and Prophylaxis by Country; Country Areas with Malaria Drug Resistance 2 Malaria Species 3 Recommended Chemoprophylaxis 4 Key Information Needed and Helpful Links to Assess Need for Prophylaxis for Select Countries; Democratic Republic of the Congo Congo-Kinshasa All Chloroquine P. falciparum 90%, P. ovale 5%, P. vivax rare Following the war, chloroquine and DDT emerged as the two principal weapons in WHO’s global eradication malaria campaign. Subsequently, chloroquine resistant P. falciparum probably arose in four separate locations starting with the Thai-Cambodian border around 1957; in Venezuela and parts of Colombia around 1960; in Papua New Guinea in the mid-1970s and in Africa starting in 1978 in Kenya and Tanzania and spreading by 1983 to Sudan, Uganda, Zambia and Malawi.

     
  7. Demigod User

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Treatment of Refractory Chronic Urticaria H1 Antihistamines Current Status and Future Directions Claritin and Plaquenil drug interactions - eHealthMe
     
  8. Meniam Well-Known Member

    Plaquenil Side Effects on Your Eyes and Vision Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug.

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