Hydroxychloroquine sarcoidosis hypercalcemia

Discussion in 'Aralen' started by 223344, 01-Mar-2020.

  1. radies Guest

    Hydroxychloroquine sarcoidosis hypercalcemia


    Extrarenal synthesis of calcitriol [1,25(OH)] is central to the pathogenesis of abnormal calcium homeostasis, but alterations in parathyroid hormone (PTH) activity and the expression of PTH‐related peptide have also been demonstrated. The immunosuppressive properties of calcitriol suggest that the raised levels seen in sarcoidosis could represent an adaptive response to the undefined antigen that causes sarcoidosis.

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    Hydroxychloroquine Plaquenil may be helpful for skin lesions and elevated blood-calcium levels. Tumor necrosis factor-alpha TNF-alpha inhibitors. These medications are commonly used to treat the inflammation associated with rheumatoid arthritis. They can also be helpful in treating sarcoidosis that hasn't responded to other treatments. Hypercalcemia, sarcoid-associated treatment 1 —Hydroxychloroquine is used to reduce urinary calcium excretion and the levels of 1,25-dihydroxyvitamin D in the serum of sarcoid patients who are unable to take corticosteroids {62}. Hypercalcemia occurs in about 10% of the patients with sarcoidosis; hypercalciuria is about three times more frequent. These abnormalities of calcium metabolism are due to dysregulated production of 1,25-OH2-D3 calcitriol by activated macrophages trapped in pulmonary alveoli and granulomatous inflammation. Undetected hypercalcemia and hypercalciuria can cause nephrocalcinosis, renal stones.

    Studies are required to determine if the currently available therapies for osteoporosis are safe and effective in sarcoidosis.. The mechanisms of abnormal calcium metabolism in sarcoidosis need to be understood when treating hypercalcaemia, hypercalcuria and corticosteroid‐induced osteoporosis.

    Hydroxychloroquine sarcoidosis hypercalcemia

    Effectiveness of Chloroquine and Hydroxychloroquine in Treating., Hydroxychloroquine Sulfate Drug Information, Professional

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  6. OK people here is the low down on hypercalcemia with sarcoidosis. Not a terribly well known complication of sarcoid in some patients, even among doctors and ERs. Sarcoidosis granuloma produce an ENZYME which catalyzes the conversion of 25hydroxyD3 in the blood into 1,25D dihydroxy D, the END PRODUCT of vitamin D metabolism.

    • Plaquenil for Hypercalcemia - Sarcoidosis - Inspire.
    • Vitamin D, Calcium, and Sarcoidosis - CHEST.
    • Immunosuppressive therapy and sarcoidosis - Cleveland Clinic.

    Jun 20, 2019 Chloroquine and hydroxychloroquine are antimalarial drugs with immunomodulating properties, which have been used for cutaneous lesions, hypercalcemia, neurological sarcoidosis, and bone lesions. Chloroquine has also been shown to be efficacious for the treatment and maintenance of chronic pulmonary sarcoidosis. 3, 4 Hydroxychloroquine 400 mg po once/day or 200 mg po bid can be effective for treating hypercalcemia, arthralgia, skin sarcoidosis, or enlarged uncomfortable or disfiguring peripheral lymph nodes. Ophthalmologic evaluation should be done before hydroxychloroquine is started and every 6 to 12 months during treatment to monitor for its ocular toxicity. Hypercalcemia occurs in sarcoidosis in 10 to 30 per cent of the cases 1-3. Its recognition and treatment are important because, if uncontrolled, it may lead to nephrocalcinosis, renal lithiasis, and irreversible renal failure 4, 5.

     
  7. oxid New Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine Phosphate - Cures Ich, Marine Velvet, Brook. Reef Medicine Series. Chloroquine Diphosphate White Spots On Fish - Chloroquine Phosphate To Treat Parasites
     
  8. sun044 New Member

    Malarivon Syrup - electronic Medicines Compendium eMC Chloroquine has been reported to reduce the bioavailability of praziquantel. Caution is advised during co-administration. Chloroquine has the potential to increase symptoms of myasthenia gravis and thus diminish effect of neostigmine and pyridostigmine. Concomitant administration of chloroquine with rabies vaccine may affect the antibody response.

    Chloroquine Indications, Side Effects, Warnings -